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There are tolerability concerns that can prevent patients from staying on medications

Older adults exhibit a heightened vulnerability to drug toxicity, primarily attributable to alterations in pharmacokinetics resulting from diminished renal function and the decline of virtually all other organ systems (Christopher et al., 2022)

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Call your healthcare provider for mild symptoms lasting more than 5-7 days, uncertainty about medication, blood sugar above 250 mg/dL (if diabetic), or new/worsening symptoms

Thus, manufacturing a milk thistle supplement entails extracting silymarin from the seeds, often at 70-80% standardized concentrations.15 Practically all of our top recommendations NOW Foods, HUM Nutrition, and Nootropics Depot fall within that range or exceed it