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Currently, there is limited interest in the non-GLP-1R obesity field, as sales for obesity drugs targeting alternative mechanisms are only forecast to generate a mere $310m in 2026

Tirzepatide exhibits C-terminal homology to exenatide and is conjugated to a C20 fatty diacid moiety via a Lys-linked hydrophilic spacer, a modification strategy similar to that employed in semaglutide [20]