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Its receptors are expressed in multiple tissues, including the heart, kidneys, lungs, and smooth muscle

That is the same circuitry that addiction hijacks

The effectiveness of once-daily subcutaneous liraglutide administration for weight loss management in adults was established in five large-scale randomized multicentre phase 3 trials [49,50,51,52,53], four of which were part of the SCALE program (Satiety and Clinical AdiposityLiraglutide Evidence in nondiabetic and diabetic individuals), leading to its approval at a dose of 3.0 mg subcutaneous once-daily (weekly increased from 0.6 mg to 3 mg/day)

Walker explains there shouldn't be a rebound because at a fundamental level, modern lifestyles have created a situation where gut and brain don't communicate well