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For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]

Co-authors include Jennifer Hwang, DO, Neda Laiteerapong, MD, Elbert Huang, MD, Dariush Mozaffarian, MD, DrPH, A

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Vitamin C is the best-studied and understood antioxidant: a substance that readily donates electrons to neutralize potentially damaging oxidative free radicals. As our cells use oxygen to make energy, they create oxygen free radicals, which must be tightly controlled or they can destroy DNA, proteins, and other key cell components

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