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[3] This suggests MOTS-c is part of the molecular signal cascade that mediates exercise adaptation, and that exogenous supplementation may partly restore the adaptive response that aging attenuates

However, TSA can effectively downregulate the expression levels of HDAC5 and TGF-1, while inhibiting the expression of EMT markers -SMA in RTECs of diabetic mice, thus significantly reducing the pathological deposition of renal ECM in diabetic mice (Xu Z

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