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Theoretical concerns: angiogenic activity warrants caution in patients with active malignancy (no tumour-promoting effects observed in any preclinical study, but oncology populations have not been formally studied)

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Maier-Begandt D, Comstra HS, Molina SA, Krger N, Ruddiman CA, Chen Y-L, Chen X, Biwer LA, Johnstone SR, Lohman AW, Good ME, DeLalio LJ, Hong K, Bacon HM, Yan Z, Sonkusare SK, Koval M, Isakson BE