GSK-J4 - H3K27 Histone Demethylases UTX and JMJD3 Inhibitor. CAS# 1373423-53-0 6050 InChi: InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8
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GSK-J4 - H3K27 Histone Demethylases UTX and JMJD3 Inhibitor. CAS# 1373423-53-0 6050 InChi: InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8GSK J4, CAS No. 1373423 53 0, is an ethyl ester derivative of GSK J1, which is the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3. The highly polar carboxylate group of GSK J1 restricts its cellular permeability, therefore GSK J4 was developed as a pro drug, masking the polarity of the acid group of the GSK J1, for cellular assays. GSK J4 could significant reduce LPS induced pro inflammatory cytokine production in
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