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In a healthy state, these fibroblast-like cells remain quiescent 34

Heparanase is a key player in renal fibrosis by regulating TGF- expression and activity

Clinicians must also remain vigilant for rare but serious complications, such as bowel obstruction, particularly in patients with preexisting motility disorders, although these risks may be overstated when comorbidities are considered (Jones and Cappola, 2025